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Lilo & Stitch Opening Weekend Box Office Predictions & Odds

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Disney hopes to rule the theaters this Memorial Day with Lilo & Stitch, the live-action animated remake of the 2002 classic. Lilo & Stitch could have the highest opening weekend of the year. What are the experts saying? View Lilo & Stitch’s opening weekend box office predictions and odds below.

What Is Lilo & Stitch About?

Ohana means family.

Lilo Pelekai (Maia Kealoha) is a young Hawaiian girl who lives with her older sister, Nani (Sydney Elizebeth Agudong), after her parents’ deaths.

Desperate for a friend, Lilo stumbles upon Stitch, a blue alien who escapes from his ship and crash-lands in Hawaii. Lilo adopts Stitch as a dog.

Stitch was genetically engineered to be a destructive force. After spending time with Lilo, Stitch reconsiders his intentions and s this new family.

However, aliens want to retrieve Stitch and bring him back to space. Meanwhile, federal agents descend upon the town with their own plans for Stitch.

Besides Kealoha and Agudong, Lilo & Stitch stars Billy Magnussen, Tia Carrere, Hannah Waddingham, Chris Sanders, Courtney B. Vance, and Zach Galifianakis.

Dean Fleischer Camp (Marcel the Shell with Shoes On) directs Lilo & Stitch from a screenplay by Chris Kekaniokalani Bright and Mike Van Waes.

Chris Sanders, who wrote and directed the 2002 animated film with Dean DeBlois, returns to voice Stitch.

Lilo & Stitch opens in theaters on May 23.

Lilo & Stitch Opening Weekend Box Office Odds

Lilo & Stitch Opening Weekend Box Office: Domestic Odds
Less than $140 million +1329
$140 million-$150 million +1150
$150 million-$160 million +426
$160 million-$170 million +223
Over $170 million +178

Odds via Polymarket on 5/21/25 at 5:30 p.m. ET

Lilo & Stitch will likely be the biggest opening of 2025 so far.

Polymarket has it tracking over $150 million (+426), with an opening north of $170 million (+178) in reach.

If Lilo & Stitch opens to $170 million, it will set the four-day Memorial Day Weekend record for the biggest domestic opening.

The previous record was held by Top Gun: Maverick, which opened to $160.5 million in 2022.

Speaking of Maverick, Tom Cruise and Mission: Impossible — The Final Reckoning is tracking to a franchise-record opening of $75 million.

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Dan Girolamo
Sports Editor

Dan is a multifaceted content creator who specializes in sports, pop culture, and entertainment. His entertainment work has been featured on Digital Trends, where he has interviewed Brendan Fraser, Jamie Lee Curtis, Alison Brie, Adam DeVine, Sadie Sink, Chris O'Dowd, Machine Gun Kelly, and Frank Grillo. Dan's entertainment work has also been featured on Coming Soon, Hidden Remote, and WatchMojo. Dan's other ion in life revolves around sports, graduating from Marist College with a degree in Sports Communication and Journalism. From columns about the latest in New York sports to gambling predictions, Dan continues to find success in written and broadcast journalism. Previous written work can be found at Unafraid Show, while broadcast clips can be seen on WAVE.tv and CBS Sports.

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Author photo
Dan Girolamo Sports Editor

Dan is a multifaceted content creator who specializes in sports, pop culture, and entertainment. His entertainment work has been featured on Digital Trends, where he has interviewed Brendan Fraser, Jamie Lee Curtis, Alison Brie, Adam DeVine, Sadie Sink, Chris O'Dowd, Machine Gun Kelly, and Frank Grillo. Dan's entertainment work has also been featured on Coming Soon, Hidden Remote, and WatchMojo. Dan's other ion in life revolves around sports, graduating from Marist College with a degree in Sports Communication and Journalism. From columns about the latest in New York sports to gambling predictions, Dan continues to find success in written and broadcast journalism. Previous written work can be found at Unafraid Show, while broadcast clips can be seen on WAVE.tv and CBS Sports.

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